12 year old James has had asthma since he was a toddler. James is a lively lad like many other boys of his age and he doesn’t let his asthma interfere with life. James loves to make his friends laugh and he is known as the class joker.
During lunchtime at school one day James is with his friends at the bottom of the school field when he feels tight chested and begins to cough. James has hay fever and the grass had been cut that morning. James doesn’t have his inhaler with him, it is in his bag in the classroom. James begins to panic when he realises this as he is finding it very hard to get his breath.
Most of James’ friends think he is joking about; it’s just James being James. Luckily, Sophie is part of the group and she knows about asthma, her sister has it quite badly. Sophie asks James where his inhaler is and he manages to tell her that it’s in the classroom. She tells the group “he’s not messing around, he’s having an asthma attack – someone go and get his inhaler, be quick.” Sophie sits with James and tries to get him to control his breathing until help arrives.
Within a couple of minutes James has his inhaler and an adult member of staff has also arrived to help. After 4 puffs of his blue inhaler James begins to feel better and is able to slowly walk to the first aid room. James needs another 2 puffs of his inhaler in the first aid room but he is feeling much better. Sophie stays with him while the staff contact his mum to collect him.
James is back at school the next day. He and his mum have a meeting with the head teacher and discuss the following:
- James must always have his reliever inhaler with him and a spare will be kept in the first aid room
- They would like to thank Sophie, she should be commended as without her actions James could have been in a very serious situation
- As James thinks the attack was triggered by grass pollen the school will try to arrange for the grass to be cut in the afternoon in future
- Staff asthma training and school policies will be updated
- An assembly about asthma will be arranged to help all pupils understand how serious asthma can be
[Guideline] National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol. 2007 Nov. 120 (5 Suppl):S94-138. [Medline].
Busse WW, Calhoun WF, Sedgwick JD. Mechanism of airway inflammation in asthma. Am Rev Respir Dis. 1993 Jun. 147(6 Pt 2):S20-4. [Medline].
Horwitz RJ, Busse WW. Inflammation and asthma. Clin Chest Med. 1995 Dec. 16(4):583-602. [Medline].
Murray JF, Nadel JA. Structure of the lungs relative to their principal function. Textbook of Respiratory Medicine. WB Saunders Co; 1988. 15-20.
Balzar S, Fajt ML, Comhair SA, Erzurum SC, Bleecker E, Busse WW, et al. Mast cell phenotype, location, and activation in severe asthma: data from the severe asthma research program. Am J Respir Crit Care Med. 2011 Feb 1. 183(3):299-309. [Medline]. [Full Text].
Gauvreau GM, Boulet LP, Cockcroft DW, et al. Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma. Am J Respir Crit Care Med. 2011 Apr 15. 183(8):1007-14. [Medline].
Anderson WJ, Watson L. Asthma and the hygiene hypothesis. N Engl J Med. 2001 May 24. 344(21):1643-4. [Medline].
Brooks C, Pearce N, Douwes J. The hygiene hypothesis in allergy and asthma: an update. Curr Opin Allergy Clin Immunol. 2013 Feb. 13 (1):70-7. [Medline].
Sears MR. Consequences of long-term inflammation. The natural history of asthma. Clin Chest Med. 2000 Jun. 21(2):315-29. [Medline].
Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med. 1999 Nov 22. 159(21):2582-8. [Medline].
Henderson WR Jr. Role of leukotrienes in asthma. Ann Allergy. 1994 Mar. 72(3):272-8. [Medline].
Beasley RW, Clayton TO, Crane J, Lai CK, Montefort SR, Mutius E, et al. Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: international study of asthma and allergies in childhood phase three. Am J Respir Crit Care Med. 2011 Jan 15. 183(2):171-8. [Medline].
Comert S, Karakaya G. Kalyoncu AF. Aspirin desensitization treatment for the management of aspirin-exacerbated respiratory disease. J Respir Res. 2016. 2:24-7.
Harding SM, Guzzo MR, Richter JE. The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms. Am J Respir Crit Care Med. 2000 Jul. 162(1):34-9. [Medline].
Tarlo SM, Balmes J, Balkissoon R, Beach J, Beckett W, Bernstein D, et al. Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement. Chest. 2008 Sep. 134(3 Suppl):1S-41S. [Medline].
Lemanske RF Jr, Jackson DJ, Gangnon RE, Evans MD, Li Z, Shult PA, et al. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol. 2005 Sep. 116(3):571-7. [Medline].
Bizzintino J, Lee WM, Laing IA, Vang F, Pappas T, Zhang G, et al. Association between human rhinovirus C and severity of acute asthma in children. Eur Respir J. 2011 May. 37(5):1037-42. [Medline]. [Full Text].
Martin RJ, Kraft M, Chu HW, Berns EA, Cassell GH. A link between chronic asthma and chronic infection. J Allergy Clin Immunol. 2001 Apr. 107(4):595-601. [Medline].
Hamilos DL. Gastroesophageal reflux and sinusitis in asthma. Clin Chest Med. 1995 Dec. 16(4):683-97. [Medline].
McFadden ER Jr. Exercise-induced airway obstruction. Clin Chest Med. 1995 Dec. 16(4):671-82. [Medline].
Randolph C. Exercise-induced asthma: update on pathophysiology, clinical diagnosis, and treatment. Curr Probl Pediatr. 1997 Feb. 27(2):53-77. [Medline].
Ito S, Noguchi E, Shibasaki M, Yamakawa-Kobayashi K, Watanabe H, Arinami T. Evidence for an association between plasma platelet-activating factor acetylhydrolase deficiency and increased risk of childhood atopic asthma. J Hum Genet. 2002. 47(2):99-101. [Medline].
Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med. 2000 May. 161(5):1720-45. [Medline].
Zucker, M. Asthma phenotype, genotype may guide future therapies. Available at http://www.pulmonaryreviews.com/jun03/pr_jun03_phenotype.html. Accessed: June 8, 2003.
Drazen JM, Yandava CN, Dube L, Szczerback N, Hippensteel R, Pillari A, et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet. 1999 Jun. 22(2):168-70. [Medline].
Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr, et al. Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol. 2007 Jun. 119(6):1423-9. [Medline].
Wechsler ME, Lehman E, Lazarus SC, Lemanske RF Jr, Boushey HA, Deykin A, et al. beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med. 2006 Mar 1. 173(5):519-26. [Medline]. [Full Text].
Cottrell L, Neal WA, Ice C, Perez MK, Piedimonte G. Metabolic abnormalities in children with asthma. Am J Respir Crit Care Med. 2011 Feb 15. 183(4):441-8. [Medline]. [Full Text].
Juel CT, Ali Z, Nilas L, Ulrik CS. Asthma and obesity: does weight loss improve asthma control? a systematic review. J Asthma Allergy. 2012. 5:21-6. [Medline].
Sonnenschein-van der Voort AM, Jaddoe VW, Raat H, Moll HA, Hofman A, de Jongste JC, et al. Fetal and infant growth and asthma symptoms in preschool children: the generation R study. Am J Respir Crit Care Med. 2012 Apr 1. 185(7):731-7. [Medline].
Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008 Jan. 31(1):143-78. [Medline]. [Full Text].
Zhang Y, McConnell R, Gilliland F, Berhane K. Ethnic differences in the effect of asthma on pulmonary function in children. Am J Respir Crit Care Med. 2011 Mar 1. 183(5):596-603. [Medline]. [Full Text].
Burrows B, Barbee RA, Cline MG, Knudson RJ, Lebowitz MD. Characteristics of asthma among elderly adults in a sample of the general population. Chest. 1991 Oct. 100(4):935-42. [Medline].
Martin AJ, Landau LI, Phelan PD. Lung function in young adults who had asthma in childhood. Am Rev Respir Dis. 1980 Oct. 122(4):609-16. [Medline].
Sly RM. Changing asthma mortality. Ann Allergy. 1994 Sep. 73(3):259-68. [Medline].
Moorman JE, Rudd RA, Johnson CA, King M, Minor P, Bailey C, et al. National surveillance for asthma--United States, 1980-2004. MMWR Surveill Summ. 2007 Oct 19. 56(8):1-54. [Medline].
National Heart, Lung, and Blood Institute Chartbook on Cardiovascular, Lung, and BloodDiseases, U.S. Department of Health and Human Services, et al. 2009. Available at http://www.nhlbi.nih.gov/resources/docs/2009_ChartBook.pdf.
Bailey WC, Richards JM Jr, Brooks CM, Soong SJ, Windsor RA, Manzella BA. A randomized trial to improve self-management practices of adults with asthma. Arch Intern Med. 1990 Aug. 150(8):1664-8. [Medline].
Ignacio-Garcia JM, Gonzalez-Santos P. Asthma self-management education program by home monitoring of peak expiratory flow. Am J Respir Crit Care Med. 1995 Feb. 151(2 Pt 1):353-9. [Medline].
Kotses H, Bernstein IL, Bernstein DI, Reynolds RV, Korbee L, Wigal JK, et al. A self-management program for adult asthma. Part I: Development and evaluation. J Allergy Clin Immunol. 1995 Feb. 95(2):529-40. [Medline].
Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004 Jan. 113(1):59-65. [Medline].
Coffman JM, Cabana MD, Yelin EH. Do school-based asthma education programs improve self-management and health outcomes?. Pediatrics. 2009 Aug. 124(2):729-42. [Medline]. [Full Text].
[Guideline] Management of Asthma Working Group. VA/DoD clinical practice guideline for management of asthma in children and adults. Washington (DC): Department of Veteran Affairs, Department of Defense; 2009. [Full Text].
Font-Ribera L, Villanueva CM, Nieuwenhuijsen MJ, et al. Swimming pool attendance, asthma, allergies, and lung function in the Avon Longitudinal Study of Parents and Children cohort. Am J Respir Crit Care Med. 2011 Mar 1. 183(5):582-8. [Medline]. [Full Text].
Shao W, Chung T, Berdon WE, Mellins RB, Griscom NT, Ruzal-Shapiro C, et al. Fluoroscopic diagnosis of laryngeal asthma (paradoxical vocal cord motion). AJR Am J Roentgenol. 1995 Nov. 165(5):1229-31. [Medline].
Morris MJ, Deal LE, Bean DR, Grbach VX, Morgan JA. Vocal cord dysfunction in patients with exertional dyspnea. Chest. 1999 Dec. 116(6):1676-82. [Medline].
Nastasi KJ, Howard DA, Raby RB, Lew DB, Blaiss MS. Airway fluoroscopic diagnosis of vocal cord dysfunction syndrome. Ann Allergy Asthma Immunol. 1997 Jun. 78(6):586-8. [Medline].
Wynn SR, O'Connell EJ, Frigas E, Payne WS, Sachs MI. Exercise-induced "asthma" as a presentation of bronchial carcinoid. Ann Allergy. 1986 Aug. 57(2):139-41. [Medline].
Rolfe LM, Rayner CF. A wheezy man with a bony abnormality. Postgrad Med J. 1999 Aug. 75(886):503-4. [Medline]. [Full Text].
Tucker GF Jr. Pulmonary migraine. Ann Otol Rhinol Laryngol. 1977 Sep-Oct. 86(5 Pt 1):671-6. [Medline].
Isselbacher KJ. Harrison's Principles of Internal Medicine. Braunwald E, Wilson JD, et al. Heart failure. 13th. McGraw-Hill; 1994. 1001.
Kim YW, Han SK, Shim YS, Kim KY, Han YC, Seo JW, et al. The first report of diffuse panbronchiolitis in Korea: five case reports. Intern Med. 1992 May. 31(5):695-701. [Medline].
Bevelaqua F, Schicchi JS, Haas F, Axen K, Levin N. Aortic arch anomaly presenting as exercise-induced asthma. Am Rev Respir Dis. 1989 Sep. 140(3):805-8. [Medline].
Newman LJ, Platts-Mills TA, Phillips CD, Hazen KC, Gross CW. Chronic sinusitis. Relationship of computed tomographic findings to allergy, asthma, and eosinophilia. JAMA. 1994 Feb 2. 271(5):363-7. [Medline].
Shapiro GG, Christie DL. Gastroesophageal reflux and asthma. Clin Rev Allergy. 1983 Mar. 1(1):39-56. [Medline].
Cuevas Hernández MM, Arias Hernández RM. [Pulmonary gammagraphy study in asthmatic children with gastroesophageal reflux]. Rev Alerg Mex. 2008 Nov-Dec. 55(6):229-33. [Medline].
Bacci E, Cianchetti S, Bartoli M, Dente FL, Di Franco A, Vagaggini B, et al. Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients. Chest. 2006 Mar. 129(3):565-72. [Medline].
Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet. 2002 Nov 30. 360(9347):1715-21. [Medline].
Matsumoto H. Serum periostin: a novel biomarker for asthma management. Allergol Int. 2014 Jun. 63 (2):153-60. [Medline].
Woods AQ, Lynch DA. Asthma: an imaging update. Radiol Clin North Am. 2009 Mar. 47(2):317-29. [Medline].
Teel GS, Engeler CE, Tashijian JH, duCret RP. Imaging of small airways disease. Radiographics. 1996 Jan. 16(1):27-41. [Medline].
Enright PL, Lebowitz MD, Cockroft DW. Physiologic measures: pulmonary function tests. Asthma outcome. Am J Respir Crit Care Med. 1994 Feb. 149(2 Pt 2):S9-18; discussion S19-20. [Medline].
Ali SS, O'Connell C, Kass L, Graff G. Single-breath counting: a pilot study of a novel technique for measuring pulmonary function in children. Am J Emerg Med. 2011 Jan. 29(1):33-6. [Medline].
Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med. 2000 Jan. 161(1):309-29. [Medline].
Anderson SD, Charlton B, Weiler JM, Nichols S, Spector SL, Pearlman DS, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009 Jan 23. 10:4. [Medline].
Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med. 2005 May 26. 352(21):2163-73. [Medline].
Rossi OV, Lähde S, Laitinen J, Huhti E. Contribution of chest and paranasal sinus radiographs to the management of acute asthma. Int Arch Allergy Immunol. 1994 Sep. 105(1):96-100. [Medline].
Pratter MR, Curley FJ, Dubois J, Irwin RS. Cause and evaluation of chronic dyspnea in a pulmonary disease clinic. Arch Intern Med. 1989 Oct. 149(10):2277-82. [Medline].
Irwin RS. Chronic cough due to gastroesophageal reflux disease: ACCP evidence-based clinical practice guidelines. Chest. 2006 Jan. 129(1 Suppl):80S-94S. [Medline].
Aras G, Kanmaz D, Kadakal F, Purisa S, Sonmez K, Tuncay E, et al. Gastroesophageal reflux disease in our asthma patients: the presence of dysphagia can influence pulmonary function. Multidiscip Respir Med. 2012 Dec 17. 7 (1):53. [Medline].
Price D, Musgrave SD, Shepstone L, et al. Leukotriene antagonists as first-line or add-on asthma-controller therapy. N Engl J Med. 2011 May 5. 364(18):1695-707. [Medline].
Chauhan BF, Ducharme FM. Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children. Cochrane Database Syst Rev. 2012 May 16. 5:CD002314. [Medline].
Bruzzese JM, Sheares BJ, Vincent EJ, et al. Effects of a School-based Intervention for Urban Adolescents with Asthma: A Controlled Trial. Am J Respir Crit Care Med. 2011 Apr 15. 183(8):998-1006. [Medline]. [Full Text].
Scott M, Roberts G, Kurukulaaratchy RJ, Matthews S, Nove A, Arshad SH. Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years. Thorax. 2012 Dec. 67(12):1046-51. [Medline].
McCormack MC, Breysse PN, Matsui EC, et al. Indoor particulate matter increases asthma morbidity in children with non-atopic and atopic asthma. Ann Allergy Asthma Immunol. 2011 Apr. 106(4):308-15. [Medline].
Tung KY, Tsai CH, Lee YL. Microsomal epoxide hydroxylase genotypes/diplotypes, traffic air pollution, and childhood asthma. Chest. 2011 Apr. 139(4):839-48. [Medline].
Sheikh A, Hurwitz B, Shehata Y. House dust mite avoidance measures for perennial allergic rhinitis. Cochrane Database Syst Rev. 2007 Jan 24. CD001563. [Medline].
Abramson MJ, Puy RM, Weiner JM. Allergen immunotherapy for asthma. Cochrane Database Syst Rev. 2003. CD001186. [Medline].
Abramson MJ, Puy RM, Weiner JM. Is allergen immunotherapy effective in asthma? A meta-analysis of randomized controlled trials. Am J Respir Crit Care Med. 1995 Apr. 151(4):969-74. [Medline].
Bruggenjurgen B, Reinhold T, Brehler R, Laake E, Wiese G, Machate U, et al. Cost-effectiveness of specific subcutaneous immunotherapy in patients with allergic rhinitis and allergic asthma. Ann Allergy Asthma Immunol. 2008 Sep. 101(3):316-24. [Medline].
Marcus P. Incorporating anti-IgE (omalizumab) therapy into pulmonary medicine practice: practice management implications. Chest. 2006 Feb. 129(2):466-74. [Medline].
Busse WW, Morgan WJ, Gergen PJ, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med. 2011 Mar 17. 364(11):1005-15. [Medline]. [Full Text].
Hanania NA, Alpan O, Hamilos DL, et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. Ann Intern Med. 2011 May 3. 154(9):573-82. [Medline].
Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014 Sep 25. 371 (13):1198-207. [Medline]. [Full Text].
Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014 Sep 25. 371 (13):1189-97. [Medline]. [Full Text].
Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012 Aug 18. 380 (9842):651-9. [Medline].
Castro M, Zangrilli J, Wechsler ME, Bateman ED, Brusselle GG, Bardin P, et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir Med. 2015 May. 3 (5):355-66. [Medline].
Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010 Jan 15. 181(2):116-24. [Medline].
Keller D. Bronchial Thermoplasty Benefits Asthma Sufferers Long Term. Medscape Medical News. Available at http://www.medscape.com/viewarticle/804695. Accessed: June 4, 2013.
Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa E Silva JR, Shah PL, et al. Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol. 2013 Aug 30. [Medline].
Boggs W. Bronchial Thermoplasty Effective for Severe Persistent Asthma. Medscape [serial online]. Available at http://www.medscape.com/viewarticle/811113. Accessed: September 30, 2013.
O'Byrne PM, Pedersen S, Carlsson LG, et al. Risks of pneumonia in patients with asthma taking inhaled corticosteroids. Am J Respir Crit Care Med. 2011 Mar 1. 183(5):589-95. [Medline].
Dhuper S, Chandra A, Ahmed A, et al. Efficacy and cost comparisons of bronchodilatator administration between metered dose inhalers with disposable spacers and nebulizers for acute asthma treatment. J Emerg Med. 2011 Mar. 40(3):247-55. [Medline].
Rowe BH, Keller JL, Oxman AD. Effectiveness of steroid therapy in acute exacerbations of asthma: a meta-analysis. Am J Emerg Med. 1992 Jul. 10(4):301-10. [Medline].
Rowe BH, Edmonds ML, Spooner CH, Diner B, Camargo CA Jr. Corticosteroid therapy for acute asthma. Respir Med. 2004 Apr. 98(4):275-84. [Medline].
Agertoft L, Pedersen S. Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med. 2000 Oct 12. 343(15):1064-9. [Medline].
Tastepe AI, Kuzucu A, Demircan S, Liman ST, Demirag F. Surgical treatment of tracheal hamartoma. Scand Cardiovasc J. 1998. 32(4):239-41. [Medline].
Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ, et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med. 2006 May 11. 354(19):1985-97. [Medline].
van den Berge M, ten Hacken NH, Cohen J, Douma WR, Postma DS. Small airway disease in asthma and COPD: clinical implications. Chest. 2011 Feb. 139(2):412-23. [Medline].
Kingston HG, Hirshman CA. Perioperative management of the patient with asthma. Anesth Analg. 1984 Sep. 63(9):844-55. [Medline].
[Guideline] Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2016. Global Initiative for Asthma (GINA). Available at http://www.ginasthma.org. 2016; Accessed: May 9, 2016.
Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, et al. Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial. Clin Exp Allergy. 2013 Jan. 43 (1):36-49. [Medline].
[Guideline] Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014 Feb. 43 (2):343-73. [Medline].
Berridge MS, Lee Z, Heald DL. Pulmonary distribution and kinetics of inhaled [11C]triamcinolone acetonide. J Nucl Med. 2000 Oct. 41(10):1603-11. [Medline].
Nelson HS. Advair: combination treatment with fluticasone propionate/salmeterol in the treatment of asthma. J Allergy Clin Immunol. 2001 Feb. 107(2):398-416. [Medline].
[Guideline] Parsons JP, Hallstrand TS, Mastronarde JG, Kaminsky DA, Rundell KW, Hull JH, et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2013 May 1. 187 (9):1016-27. [Medline].
Tantisira KG, Lasky-Su J, Harada M, et al. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011 Sep 29. 365(13):1173-83. [Medline].
Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010 Oct 28. 363(18):1715-26. [Medline]. [Full Text].
Kerstjens HA, Engel M, Dahl R, Paggiaro P, Beck E, Vandewalker M, et al. Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy. N Engl J Med. 2012 Sep 2. [Medline].
Rank MA, Liesinger JT, Ziegenfuss JY, Branda ME, Lim KG, Yawn BP, et al. The impact of asthma medication guidelines on asthma controller use and on asthma exacerbation rates comparing 1997-1998 and 2004-2005. Ann Allergy Asthma Immunol. 2012 Jan. 108(1):9-13. [Medline].
Brooks M. FDA Oks New Maintenance Asthma Treatment Arnuity Ellipta. Medscape Medical News. Available at http://www.medscape.com/viewarticle/830213. Accessed: August 23, 2014.
Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet. 2016 Oct 29. 388 (10056):2115-2127. [Medline].
FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M, et al. Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2016 Oct 29. 388 (10056):2128-2141. [Medline].
Nair P, Wenzel S, Rabe KF, Bourdin A, Lugogo NL, Kuna P, et al. Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma. N Engl J Med. 2017 Jun 22. 376 (25):2448-2458. [Medline].